50293-90-8 Levalbuterol hydrochloride AKSci S105
 
 
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  S105    AKSci Reference Standard
Levalbuterol hydrochloride
, 98% (HPLC)
 
(R)-salbutamol hydrochloride
Levosalbutamol hydrochloride




IDENTITY
CAS Number:50293-90-8
MDL Number:MFCD08067728
MF:C13H21NO3.HCl
MW:275.77
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:LCMS, HPLC, Polarimetry
Physical Form:White to tan crystalline powder
Melting Point:188-195°C
Optical Rotation:-25.0° - -35.0° (c=0.1, H2O)
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:H2O: =15 mg/mL
Application(s):beta2-Adrenergic receptor agonist
Form:HCl salt

REVIEW

 Activation of beta2-adrenergic receptors on airway smooth muscle leads to the activation of adenylcyclase and to an increase in the intracellular concentration of cyclic-3'', 5''-adenosine monophosphate (cyclic AMP). This increase in cyclic AMP leads to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation. Levalbuterol relaxes the smooth muscles of all airways, from the trachea to the terminal bronchioles. Levalbuterol acts as a functional antagonist to relax the airway irrespective of the spasmogen involved, thus protecting against all bronchoconstrictor challenges. Increased cyclic AMP concentrations are also associated with the inhibition of release of mediators from mast cells in the airway.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H302; H315; H318; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P310; P321; P330; P332+P313; P362; P403+P233; P405; P501


Current as of October 20, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Adrenergic Agonists


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