76494-51-4 Ligustrazine HCl AKSci R879
 
 
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  R879    
Ligustrazine HCl, 98% (HPLC)
 



IDENTITY
CAS Number:76494-51-4
MDL Number:MFCD01109103
MF:C8H12N2.HCl
MW:172.66
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:90-93°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Inhibitory effect on phosphodiesterase and modulates calcium ion mobility

REVIEW
 Ligustrazine hydrochloride is the salt form of tetramethylpyrazine, a natural product from Rhizoma Chuanxiong containing a pyrazine ring, which has been widely used in China for treatment of heart diseases. Ligustrazine, has an inhibitory effect on phosphodiesterase and modulates calcium ion mobility that is associated with heart disease and the cardioprotective effects.

REFERENCES
[1]Kwan, Chiu Yin; Plant-derived drugs acting on cellular Ca2+ mobilization in vascular smooth muscle: tetramethylpyrazine and tetrandrine. Stem Cells (Miamisburg, OH, United States) (1994), 12(1), 64-7.
[2] Ohta A, Yamada K. Physiological and pharmacological activities of simple alkyl- and arylpyrazines. Yakugaku Zasshi. 1997 Jul;117(7):435-47.
[3] Wang X, Chen X. Study on the effects of tetramethylpyrazine on tumor cells: survey and prospects. Zhongguo Zhong Yao Za Zhi. 2003 Apr;28(4):295-8.
[4] Cheng, Xian-chao; Liu, Xin-yong; Xu, Wen-fang; Recent advances in the structural modification of ligustrazine and cerebro/cardiovascular activity of ligustrazine derivatives. Drugs of the Future (2005), 30(10), 1059-1065.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 26, 2024


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