70458-95-6 Pefloxacin mesylate AKSci R834
 
 
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  R834    
Pefloxacin mesylate
, 98%
 
1-Ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid mesylate




IDENTITY
CAS Number:70458-95-6
MDL Number:MFCD09028102
MF:C17H20FN3O3.CH3SO3H
MW:333.36
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White or light yellow crystalline powder
Melting Point:250-263°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Form:Mesylate

REVIEW

 The bactericidal action of pefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.

REFERENCES
[1]Radi, A.; Analytical and Bioanalytical Chemistry 2005, V381(2), P451-455.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 19, 2019


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antibacterials, Quinolones


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