83435-67-0 Delapril HCl AKSci R741

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R741 AKSci Reference Standard
Delapril HCl, 98% (HPLC)

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N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-L-alanyl-N-(2,3-dihydroinden-2-yl)glycine Hydrochloride

IDENTITY
CAS Number:	83435-67-0
MDL Number:	MFCD00884619
MF:	C26H32N2O5.HCl
MW:	489.009

SPECIFICATIONS & PROPERTIES
Purity:	98% (HPLC)
Spectra:	LCMS, HPLC, Polarimetry
Physical Form:	Colorless plates
Melting Point:	166-170°C (dec)
Optical Rotation:	+18.5° (c=1, in methanol)
Long-Term Storage:	Store at room temperature

BIOLOGICAL INFO
Application(s):	ACE inhibitor
Form:	HCl salt

REVIEW
Delapril, a nonsulfhydryl angiotensin converting enzyme (ACE) inhibitor, is used for the treatment of hypertension in a number of European and Asian countries. Delapril has an indanylglycine moiety differing from the proline moiety of captopril or enalapril, is an esterified prodrug that is converted in vivo to its active metabolite, an 5-hydroxy-indane diacid.

REFERENCES

[1]	Shionoiri H; Yasuda G; Ikeda A; Ohta T; Miyajima E; Kaneko Y; Pharmacokinetics and depressor effect of delapril in patients with essential hypertension. Clinical pharmacology and therapeutics (1987), 41(1), 74-9.
[2]	Saito S; Matsui S; Fukushima S; Watanabe M; Waga T; Kajiwara Y; Shirota M; Iijima M; Kitabatake K; Synthesis and angiotension converting enzyme inhibitory activity of L-lysyl-N-substituted glycine derivatives Arzneimittel-Forschung (1989), 39(12), 1558-61.
[3]	Saruta T, Nishikawa K. Characteristics of a new angiotensin converting enzyme inhibitor: delapril. Am J Hypertens. 1991 Jan;4(1 Pt 2):23S-28S.
[4]	Razzetti R, Acerbi D. Pharmacokinetic and pharmacologic properties of delapril, a lipophilic nonsulfhydryl angiotensin-converting enzyme inhibitor. Am J Cardiol. 1995 Jun 16;75(18):7F-12F.