99522-79-9 Pranidipine AKSci R730
 
 
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  R730    AKSci Reference Standard
Pranidipine
, 98% (HPLC)
 



IDENTITY
CAS Number:99522-79-9
MDL Number:MFCD00865896
MF:C25H24N2O6
MW:448.47
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:Yellow crystalline powder
Melting Point:140-146°C
Boiling Point:618.9°C at 760 mmHg
Flash Point:328.1°C
Density:1.254 g/cm3
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Application(s):Calcium channel blocker

REVIEW

 Pranidipine is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive agent. Pranidipine has a high affinity for Ca channels or T-tubule membranes, and strongly supports the membrane-bilayer pathway hypothesis, which assumes the partitioning of the drug into the lipid bilayer before binding to Ca channels as an explanation of its long-lasting action compared to other dihydropyridines.

REFERENCES
[1]Kutsuma, Teruo; Ikawa, Hiroshi; Sato, Yoshiaki 1,4-Dihydropyridine derivatives and pharmaceutical compositions comprising them Eur. Pat. Appl. (1985), EP 161877 A2 19851121.
[2] Nishitani, Shinji; Minamikawa, Junichi; Kano, Masanobu; Otsubo, Junichiro; Manabe, Yoshiaki Dihydropyridinedicarboxylates Eur. Pat. Appl. (1986), EP 173126 A1 19860305.
[3] Broadhurst P; Brigden G; Hittel N; Lahiri A; Raftery E B Prolonged hypotensive effect of OPC-13340: a new, once-daily calcium channel blocking drug European heart journal (1991), 12(3), 434-8.
[4] Rosenthal J; Hittel N; Stumpe K O Pranidipine, a novel calcium antagonist, once daily, for the treatment of hypertension: a multicenter, double-blind, placebo-controlled dose-finding study Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy (1996), 10(1), 59-66.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 20, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers


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