REVIEW Pranidipine is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive agent. Pranidipine has a high affinity for Ca channels or T-tubule membranes, and strongly supports the membrane-bilayer pathway hypothesis, which assumes the partitioning of the drug into the lipid bilayer before binding to Ca channels as an explanation of its long-lasting action compared to other dihydropyridines.
REFERENCES
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Kutsuma, Teruo; Ikawa, Hiroshi; Sato, Yoshiaki 1,4-Dihydropyridine derivatives and pharmaceutical compositions comprising them Eur. Pat. Appl. (1985), EP 161877 A2 19851121.
Broadhurst P; Brigden G; Hittel N; Lahiri A; Raftery E B Prolonged hypotensive effect of OPC-13340: a new, once-daily calcium channel blocking drug European heart journal (1991), 12(3), 434-8.
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Rosenthal J; Hittel N; Stumpe K O Pranidipine, a novel calcium antagonist, once daily, for the treatment of hypertension: a multicenter, double-blind, placebo-controlled dose-finding study Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy (1996), 10(1), 59-66.
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