REVIEW Pranidipine is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive agent. Pranidipine has a high affinity for Ca channels or T-tubule membranes, and strongly supports the membrane-bilayer pathway hypothesis, which assumes the partitioning of the drug into the lipid bilayer before binding to Ca channels as an explanation of its long-lasting action compared to other dihydropyridines.
Kutsuma, Teruo; Ikawa, Hiroshi; Sato, Yoshiaki 1,4-Dihydropyridine derivatives and pharmaceutical compositions comprising them Eur. Pat. Appl. (1985), EP 161877 A2 19851121.
Broadhurst P; Brigden G; Hittel N; Lahiri A; Raftery E B Prolonged hypotensive effect of OPC-13340: a new, once-daily calcium channel blocking drug European heart journal (1991), 12(3), 434-8.
Rosenthal J; Hittel N; Stumpe K O Pranidipine, a novel calcium antagonist, once daily, for the treatment of hypertension: a multicenter, double-blind, placebo-controlled dose-finding study Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy (1996), 10(1), 59-66.
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.
Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.