REVIEW Pranidipine is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive agent. Pranidipine has a high affinity for Ca channels or T-tubule membranes, and strongly supports the membrane-bilayer pathway hypothesis, which assumes the partitioning of the drug into the lipid bilayer before binding to Ca channels as an explanation of its long-lasting action compared to other dihydropyridines.
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Rosenthal J; Hittel N; Stumpe K O Pranidipine, a novel calcium antagonist, once daily, for the treatment of hypertension: a multicenter, double-blind, placebo-controlled dose-finding study Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy (1996), 10(1), 59-66.
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