99522-79-9 Pranidipine AKSci R730

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R730
Pranidipine, 98% (HPLC)

IDENTITY
CAS Number:	99522-79-9
MDL Number:	MFCD00865896
MF:	C25H24N2O6
MW:	448.47

SPECIFICATIONS & PROPERTIES
Purity:	98% (HPLC)
Spectra:	NMR, LCMS, FT-IR, HPLC
Physical Form:	Yellow crystalline powder
Melting Point:	140-146°C
Boiling Point:	618.9°C at 760 mmHg
Flash Point:	328.1°C
Density:	1.254 g/cm3
Long-Term Storage:	Store long-term at 2-8°C

BIOLOGICAL INFO
Application(s):	Calcium channel blocker

REVIEW
Pranidipine is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive agent. Pranidipine has a high affinity for Ca channels or T-tubule membranes, and strongly supports the membrane-bilayer pathway hypothesis, which assumes the partitioning of the drug into the lipid bilayer before binding to Ca channels as an explanation of its long-lasting action compared to other dihydropyridines.

REFERENCES

[1]	Kutsuma, Teruo; Ikawa, Hiroshi; Sato, Yoshiaki 1,4-Dihydropyridine derivatives and pharmaceutical compositions comprising them Eur. Pat. Appl. (1985), EP 161877 A2 19851121.
[2]	Nishitani, Shinji; Minamikawa, Junichi; Kano, Masanobu; Otsubo, Junichiro; Manabe, Yoshiaki Dihydropyridinedicarboxylates Eur. Pat. Appl. (1986), EP 173126 A1 19860305.
[3]	Broadhurst P; Brigden G; Hittel N; Lahiri A; Raftery E B Prolonged hypotensive effect of OPC-13340: a new, once-daily calcium channel blocking drug European heart journal (1991), 12(3), 434-8.
[4]	Rosenthal J; Hittel N; Stumpe K O Pranidipine, a novel calcium antagonist, once daily, for the treatment of hypertension: a multicenter, double-blind, placebo-controlled dose-finding study Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy (1996), 10(1), 59-66.