71731-58-3 Tiquizium bromide AKSci R610
 
 
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  R610    
Tiquizium bromide, 98% (HPLC)
 
Thiaton
IDENTITY
CAS Number:71731-58-3
MDL Number:MFCD00941407
MF:C19H24NS2.Br
MW:410.44
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:295-297°C (dec)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Tiquizium bromide is a quaternary ammonium salt, an antimuscarinic agent used as a antispasdomdic pain mediating drug. The compound also demonstrates bronchodilatory effect on airway smooth muscle in vitro, and also in patients with chronic obstructive pulmonary disease (COPD).

REFERENCES
[1]Koshinaka, Eiichi; Ogawa, Nobuo; Kurata, Sakae; Yamagishi, Kagari; Kubo, Shinji; Matsubara, Issei; Kato, Hideo Studies on antispasmodics. I. Synthesis and anticholinergic activity of 1-, 2-, and 3-diarylmethylenequinolizidine quaternary ammonium salts. Chemical & Pharmaceutical Bulletin (1979), 27(6), 1454-63.
[2] Oshita, Masafumi; Ohashi, Tetsuo; Morikawa, Kouji; Kato, Hideo; Ito, Yasuo; Muramatsu, Ikunobu; Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors. Japanese Journal of Pharmacology (1987), 44(2), 222-4.
[3] Oshita M, Ohashi T, Morikawa K, Kato H, Ito Y, Muramatsu I. Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors. Jpn J Pharmacol. 1987 Jun;44(2):222-4.
[4] Shioya, T.; Kagaya, M.; Sano, M.; Itaba, M.; Shindo, T.; Miura, M.; Antimuscarinic effect of tiquizium bromide in vitro and in vitro. European Journal of Clinical Pharmacology (1996), 50(5), 375-380.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 29, 2025


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CATEGORIES
 APIs and Bioactives > AChR Antagonists


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