REVIEW Tiquizium bromide is a quaternary ammonium salt, an antimuscarinic agent used as a antispasdomdic pain mediating drug. The compound also demonstrates bronchodilatory effect on airway smooth muscle in vitro, and also in patients with chronic obstructive pulmonary disease (COPD).
REFERENCES
[1]
Koshinaka, Eiichi; Ogawa, Nobuo; Kurata, Sakae; Yamagishi, Kagari; Kubo, Shinji; Matsubara, Issei; Kato, Hideo Studies on antispasmodics. I. Synthesis and anticholinergic activity of 1-, 2-, and 3-diarylmethylenequinolizidine quaternary ammonium salts. Chemical & Pharmaceutical Bulletin (1979), 27(6), 1454-63.
[2]
Oshita, Masafumi; Ohashi, Tetsuo; Morikawa, Kouji; Kato, Hideo; Ito, Yasuo; Muramatsu, Ikunobu; Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors. Japanese Journal of Pharmacology (1987), 44(2), 222-4.
[3]
Oshita M, Ohashi T, Morikawa K, Kato H, Ito Y, Muramatsu I. Studies on the affinity and selectivity of tiquizium bromide (HSR-902), a novel spasmolytic agent, for muscarinic receptors. Jpn J Pharmacol. 1987 Jun;44(2):222-4.
[4]
Shioya, T.; Kagaya, M.; Sano, M.; Itaba, M.; Shindo, T.; Miura, M.; Antimuscarinic effect of tiquizium bromide in vitro and in vitro. European Journal of Clinical Pharmacology (1996), 50(5), 375-380.
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