50924-49-7 Mizoribine AKSci Q571
 
 
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  Q571    
Mizoribine, 98% (HPLC)
 
4-Carbamoyl-1-b-D-ribofuranosylimidazolium-5-olate
IDENTITY
CAS Number:50924-49-7
MDL Number:MFCD00057221
MF:C9H13N3O6
MW:259.22
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:219-225°C
Optical Rotation:-27° to -25° (c=2,H2O)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO
Application(s):Imidazole nucleoside and an immunosuppressive agent
Form:Free base
Research Area:Immunology

REVIEW
 Mizoribine (trade name Bredinin) is a natural product, first isolated from the mould Eupenicillium brefeldianum, in Japan in 1971. Mizoribine, an imidazole nucleoside is an immunosuppressive drug that has been used in kidney transplantation, which is the optimal form of therapy for children and adolescents with end-stage kidney disease. The compound has also been used to treat steroid-resistant nephrotic syndrome, IgA nephropathy, lupus, as well as for adults with rheumatoid arthritis, lupus nephritis and other rheumatic diseases. MZB mode of action is via selective inhibition of inosine monophosphate synthetase and guanosine monophosphate synthetase, resulting in the complete inhibition of guanine nucleotide synthesis without incorporation into nucleotides. It arrests DNA synthesis in the S phase of cellular division.

REFERENCES
[1]Ishikawa H. Mizoribine and mycophenolate mofetil. Curr Med Chem. 1999 Jul;6(7):575.
[2] Yokota S. Mizoribine: mode of action and effects in clinical use. Pediatr Int. 2002 Apr;44(2):196-8.
[3] Takei S. Mizoribine in the treatment of rheumatoid arthritis and juvenile idiopathic arthritis. Pediatr Int. 2002 Apr;44(2):205-9.
[4] Tsuzuki K. Role of mizoribine in renal transplantation. Pediatr Int. 2002 Apr;44(2):224-31.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H315; H319; H335; H314; H318; H315; H319; H335; H302; H402; H302; H315; H319;

Precautionary Statements
P201; P202; P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P308+P313; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 24, 2024


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