REVIEW Metoprolol succinate is the extended-release formulation of the active substance metoprolol, a selective beta1 receptor blocker used in treatment of several cardiovascular diseases. It is used for a number of conditions including hypertension, angina, acute myocardial infarction, supraventricular tachycardia, ventricular tachycardia, congestive heart failure, and prevention of migraine headaches. Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at cardiac beta1 receptors, resulting in a decrease in heart rate, cardiac output, and blood pressure. Due to its selectivity for cardiac beta1 receptors, metoprolol is also prescribed for anxiety disorders.
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'D''Souza, Valerian M.; Ghogare, Anil B Process of making dicarboxylic salts of metoprolol PCT Int. Appl. (2010), WO 2010058407 A2 20100527.'
Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet. 1999 Jun 12;353(9169):2001-7.