518-34-3 Tetrandrine AKSci O972
 
 
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  O972    AKSci Reference Standard
Tetrandrine
, 98% (HPLC)
 



IDENTITY
CAS Number:518-34-3
MDL Number:MFCD08689909
MF:C38H42N2O6
MW:622.75
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:219-222°C
Optical Rotation:+285° (c=1, CHCl3)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Calcium channel blocker
Form:Free Base
Research Area:Cancer

REVIEW

 Tetrandrine a bis-benzylisoquinoline alkaloid, a principle from a traditional Chinese medicine of the root of Stephania tetrandra S Moore, and other Chinese and Japanese herbs,and is a calcium channel blocker with a wide range of biological effects. Tetrandrine demonstrates antiinflammatory, antifibrogenetic, immunomodulating and antioxidant effects, it also presents antiallergic effects, inhibitory effects on pulmonary vessels and airway smooth muscle contraction, and platelet aggregation via its nonspecific calcium channel antagonism that suggested its potential in the treatment of asthma, pulmonary hypertension and chronic obstructive pulmonary disease.

REFERENCES
[1]Chen Y, Tsai YH, Tseng SH. The potential of tetrandrine as a protective agent for ischemic stroke. Molecules. 2011 Sep 16;16(9):8020-32.
[2] Chen Y, Tseng SH. The Potential of Tetrandrine against Gliomas. Anticancer Agents Med Chem. 2010 Sep;10(7):534-42.
[3] Wang G, Lemos JR, Iadecola C. Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol Sci. 2004 Mar;25(3):120-3.
[4] Xie QM, Tang HF, Chen JQ, Bian RL, Pharmacological actions of tetrandrine in inflammatory pulmonary diseases. Acta Pharmacol Sin. 2002 Dec;23(12):1107-13.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 6, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Calcium channel blockers, Alkaloids


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