REVIEW Tetrandrine a bis-benzylisoquinoline alkaloid, a principle from a traditional Chinese medicine of the root of Stephania tetrandra S Moore, and other Chinese and Japanese herbs,and is a calcium channel blocker with a wide range of biological effects. Tetrandrine demonstrates antiinflammatory, antifibrogenetic, immunomodulating and antioxidant effects, it also presents antiallergic effects, inhibitory effects on pulmonary vessels and airway smooth muscle contraction, and platelet aggregation via its nonspecific calcium channel antagonism that suggested its potential in the treatment of asthma, pulmonary hypertension and chronic obstructive pulmonary disease.
REFERENCES
[1]
Chen Y, Tsai YH, Tseng SH. The potential of tetrandrine as a protective agent for ischemic stroke. Molecules. 2011 Sep 16;16(9):8020-32.
[2]
Chen Y, Tseng SH. The Potential of Tetrandrine against Gliomas. Anticancer Agents Med Chem. 2010 Sep;10(7):534-42.
[3]
Wang G, Lemos JR, Iadecola C. Herbal alkaloid tetrandrine: from an ion channel blocker to inhibitor of tumor proliferation. Trends Pharmacol Sci. 2004 Mar;25(3):120-3.
[4]
Xie QM, Tang HF, Chen JQ, Bian RL, Pharmacological actions of tetrandrine in inflammatory pulmonary diseases. Acta Pharmacol Sin. 2002 Dec;23(12):1107-13.
Add to Favorites 
Delete from Favorites 
