126544-47-6 Ciclesonide AKSci O945
 
 
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  O945    AKSci Reference Standard
Ciclesonide
, 98% (HPLC)
 
Alvesco
Omnaris
Omniair




IDENTITY
CAS Number:126544-47-6
MDL Number:MFCD00866004
MF:C32H44O7
MW:540.69
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:206-213°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):A glucocorticoid microemulsion preparation

REVIEW

 Ciclesonide is a synthetic glucocorticoid used to treat obstructive airway diseases. It is a pro-drug that is enzymatically hydrolyzed to a pharmacologically active metabolite, C21-desisobutyryl-ciclesonide (des-ciclesonide or RM1) following intranasal application. Corticosteroids have been shown to have a wide range of effects on multiple cell types and mediators involved in allergic inflammation.

REFERENCES
[1]Christie, Pandora. Ciclesonide. A novel inhaled corticosteroid for asthma. Drugs of Today. (2004) 40(7): 569-576.
[2] Reynolds, Neil A.; Scott, Lesley J. Ciclesonide. Drugs. (2004) 64(5): 511-519.
[3] Meltzer, Eli O.; Derendorf, Hartmut. The systemic safety of inhaled corticosteroid therapy: a focus on ciclesonide. Annals of Allergy, Asthma, & Immunology. (2006) 97(2): 149-157.
[4] Mealy, N. E.; Bayes, M.; Castaner, J.Ciclesonide: Treatment of allergic rhinitis antiallergy/antiasthmatic BY-9010 B-9207-015 Drugs of the Future (2001), 26(11), 1033-1039.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of March 2, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Steroid Hormones


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