REVIEW Liensinine (neferine), a isoquinoline alkaloid, extracted from the green seed embryo of Nelumbo nucifera Gaertn has been shown to have anti-arrhythmic action, its mechanism may be related to blockade of Ca2+ and Na+ influx. Liensinene has also shown a potential neuroprotective effect in rats, in regard to focal cerebral ischemia, whereby liensinen inhibited the expression of C-Fos, which significantly increased after 24-h ischemia without the treatment of the compound.
Chao, Yuan Chih; Chou, Yun-Li; Yang, Pao-Chin; Chao, Chen-Ku; Alkaloids of embryo Nelumbo nucifera. I. Isolation and characterization of liensinine , Scientia Sinica (English Edition) (1962), 11, 215-19.
Hsieh, Yu-Yuan; Pan, Pei-Chuan; Chen, Wen-Chi; Kao, Yee-Sheng; Alkaloids of Nelumbo nucifera. IV. Total synthesis of liensinine Scientia Sinica (English Edition) (1964), 12(12), 2020-5.
Wang, J. L.; Nong, Y.; Jing, M. X. Effects of liensinine on hemodynamics in rats and the physiologic properties of isolated rabbit atria Yaoxue Xuebao (1992), 27(12), 881-5.
Wang, J. L.; Nong, Y.; Xia, G. J.; Yao, W. X.; Jiang, M. X. Effects of liensinine on slow action potential in myocardium and slow inward current in canine cardiac Purkinje fibers. Yaoxue Xuebao (1993), 28(11), 812-16.