519-02-8 Matrine AKSci O723
 
 
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  O723    AKSci Bulk Reagent
Matrine, 98% (GC)
 
Sophocarpidine
Matridin-15-one
IDENTITY
CAS Number:519-02-8
MDL Number:MFCD00210527
MF:C15H24N2O
MW:248.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (GC)
Melting Point:76°C
Boiling Point:223°C
Optical Rotation:+31.0 to +34.0° (c=1, EtOH)
Density:1.088
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in water, benzene, chloroform, ether.
Application(s):An alkaloid that displays kappa-opioid receptor agonism

REVIEW
 Matrine is a optically active natural occurring alkaloid found in plants from the Sophora genus, and is a component of the traditional Chinese medical herb Sophora flavescens Ait. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and mui-receptor agonist. Matrine potent in vitro and in vivo antitumor activities are via inhibition of cell proliferation, inducing differation and apoptosis, reducing invasion and metastasis of tumor cell. Matrine and the related compound oxymatrine also have an antifeedant effect against Formosan subterranean termite.

REFERENCES
[1]Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, Luan G, Yagasaki K, Zhang G. Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology. 2009 Apr;59(3):191-200.
[2] Ma L, Wen S, Zhan Y, He Y, Liu X, Jiang J. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med. 2008 Feb;74(3):245-51.
[3] Xiao P, Kubo H, Ohsawa M, Higashiyama K, Nagase H, Yan YN, Li JS, Kamei J, Ohmiya S. kappa-Opioid receptor-mediated antinociceptive effects of stereoisomers and derivatives of (+)-matrine in mice. Planta Med. 1999 Apr;65(3):230-3.
[4] Higashiyama K, Takeuchi Y, Yamauchi T, Imai S, Kamei J, Yajima Y, Narita M, Suzuki T.Implication of the descending dynorphinergic neuron projecting to the spinal cord in the (+)-matrine- and (+)-allomatrine-induced antinociceptive effects. Biol Pharm Bull. 2005 May;28(5):845-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of December 30, 2024


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CATEGORIES
 APIs and Bioactives > Alkaloids


PubChem
  @PubMed