An alkaloid that displays kappa-opioid receptor agonism
REVIEW Matrine is a optically active natural occurring alkaloid found in plants from the Sophora genus, and is a component of the traditional Chinese medical herb Sophora flavescens Ait. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and mui-receptor agonist. Matrine potent in vitro and in vivo antitumor activities are via inhibition of cell proliferation, inducing differation and apoptosis, reducing invasion and metastasis of tumor cell. Matrine and the related compound oxymatrine also have an antifeedant effect against Formosan subterranean termite.
Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, Luan G, Yagasaki K, Zhang G. Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology. 2009 Apr;59(3):191-200.
Ma L, Wen S, Zhan Y, He Y, Liu X, Jiang J. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med. 2008 Feb;74(3):245-51.
Xiao P, Kubo H, Ohsawa M, Higashiyama K, Nagase H, Yan YN, Li JS, Kamei J, Ohmiya S. kappa-Opioid receptor-mediated antinociceptive effects of stereoisomers and derivatives of (+)-matrine in mice. Planta Med. 1999 Apr;65(3):230-3.
Higashiyama K, Takeuchi Y, Yamauchi T, Imai S, Kamei J, Yajima Y, Narita M, Suzuki T.Implication of the descending dynorphinergic neuron projecting to the spinal cord in the (+)-matrine- and (+)-allomatrine-induced antinociceptive effects. Biol Pharm Bull. 2005 May;28(5):845-8.