REVIEW Cefoselis sulfate is broad-spectrum, oxime-type 4th generation cephalosporin antibiotic active against gram-positive and gram-negative aerobic bacteria. It occasionally induces seizures and convulsion in elder and renal failure patients by virtue of inhibiting GABA(A)-R in a competitive manner. Cefoselis sulfate inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). This inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
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