1063-77-0 Nomilin AKSci O626
 
 
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  O626    
Nomilin, 98% (HPLC)
 
1-(Acetyloxy)-1,2-dihydroobacunoic acid e-lactone
IDENTITY
CAS Number:1063-77-0
MDL Number:MFCD00075979
MF:C28H34O9
MW:514.56
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:259-263°C
Optical Rotation:-78.5° (c=1, Acetone)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Carciogenesis inhibitor, A inducer of phase II detoxifying enzymes

REVIEW
 Nomilin is a natural product isolated from grapefruit seed and varying Citrus fruits. The compound is an inducer of Phase II detoxifying enzymes and inhibitor of chemically induced carcinogenesis. The compound has been observed to have 2.9-8.3 times the antioxidant activity when compared to Vitamin C. Nomilin has also been documented to inhibit HIV-1 injection in human mononuclear cells. In a dose dependent manner Nomilin has increased the activity of GST in the liver of rats.

REFERENCES
[1]Miller, E.G., et al. 1989. Carcinogenesis. 10: 1535-1537. PMID: 2502323
[2] Battinelli, L., et al. 2003. Planta Med. 69: 910-913. PMID: 14648393
[3] Poulose, S.M., et al. 2006. Nutr Cancer. 56: 103-112. PMID: 17176224
[4] Perez, J.L., et al. 2010. BMC Complement Altern Med. 10: 51. PMID: 20846448

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of December 21, 2024


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CATEGORIES
 APIs and Bioactives > Natural Products


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