110221-44-8 Temocapril HCl AKSci O388
 
 
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  O388    
Temocapril HCl
, 98%
 



IDENTITY
CAS Number:110221-44-8
MDL Number:MFCD00933433
MF:C23H28N2O5S2.HCl
MW:513.076
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white crystalline powder
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Application(s):Angiotensin-converting enzyme (ACE) inhibitor
Form:HCl salt

REVIEW

 Temocapril HCl is a long-acting angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension. It is a prodrug with a thiazepine ring, with temocaprilat being its active form. It is currently only approved for use in Japan.

REFERENCES
[1]Jia Nan; Okamoto Hiroshi; Shimizu Toshihiro; Chiba Satoru; Matsui Yutaka; Sugawara Takeshi; Akino Masatoshi; Kitabatake Akira; A newly developed angiotensin II type 1 receptor antagonist, CS866, promotes regression of cardiac hypertrophy by reducing integrin beta1 expression Hypertension research: official journal of the Japanese Society of Hypertension (2003), 26(9), 737-42.
[2] Yasunari K, Maeda K, Nakamura M, Watanabe T, Yoshikawa J, Asada A. Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile. Cardiovasc Drug Rev. 2004 Fall;22(3):189-98.
[3] Koike, Hiroyuki; Yanagisawa, Hiroaki; Ikeda, Toshihiko; Manabe, Sunao; Ishikawa, Seishio; Kawahara, Yukinori Temocapril; (CS-622), a novel angiotensin converting enzyme inhibitor. Sankyo Kenkyusho Nenpo (1992), 44, 1-81.
[4] Shionoiri, Hiroshi; Ochiai, Hisao; Hiroto, Seiji; ACE inhibitor, temocapril hydrochloride, excreted from bile and kidney. Cardiac Practice (1995), 6(4), 487-94.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 27, 2019


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CATEGORIES

 APIs and Bioactives > ACE Inhibitors


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