104757-53-1 Barnidipine HCl AKSci O375
 
 
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  O375    
Barnidipine HCl, 98% (HPLC)
 



IDENTITY
CAS Number:104757-53-1
MDL Number:MFCD00915772
MF:C27H29N3O6.HCl
MW:529.00
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:225-232°C
Optical Rotation:+116 ~ +120° (c=1, MeOH)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Calcium channel blocker
Form:HCl salt

REVIEW
 Barnidipine hydrochloride is a chiral dihydropyridine calcium channel blocker used as an antihypertensive. It is an L-type CCB with high affinity for [3H]nitrendipine binding sites.

REFERENCES
[1]Tamazawa, Kazuharu; Arima, Hideki; Kojima, Tadao; Isomura, Yasuo; Okada, Minoru; Fujita, Shigeo; Furuya, Toshio; Takenaka, Toichi; Inagaki, Osamu; Terai, Michio Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Journal of Medicinal Chemistry (1986), 29(12), 2504-11.
[2] Arima, Hideki; Tamazawa, Kazuharu A process for the preparation of (4S)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid (3S)-3-(1-benzyl)-3-pyrrolidinyl) ester 5-methyl ester as a vasodilator and antihypertensive Jpn. Kokai Tokkyo Koho (1987), JP 62174071 A 19870730.
[3] Liau CS. Barnidipine: a new calcium channel blocker for hypertension treatment. Expert Rev Cardiovasc Ther. 2005 Mar;3(2):207-13.
[4] Malhotra HS, Plosker GL Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of July 1, 2025


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CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


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