104757-53-1 Barnidipine HCl AKSci O375

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O375
Barnidipine HCl, 98% (HPLC)

IDENTITY
CAS Number:	104757-53-1
MDL Number:	MFCD00915772
MF:	C27H29N3O6.HCl
MW:	529.00

SPECIFICATIONS & PROPERTIES
Purity:	98% (HPLC)
Spectra:	FT-IR, LCMS, HPLC
Physical Form:	Light yellow powder or crystalline powder
Melting Point:	225-232°C
Optical Rotation:	+116 ~ +120° (c=1, MeOH)
Long-Term Storage:	Store at room temperature

BIOLOGICAL INFO
Application(s):	Calcium channel blocker
Form:	HCl salt

REVIEW
Barnidipine hydrochloride is a chiral dihydropyridine calcium channel blocker used as an antihypertensive. It is an L-type CCB with high affinity for [3H]nitrendipine binding sites.

REFERENCES

[1]	Tamazawa, Kazuharu; Arima, Hideki; Kojima, Tadao; Isomura, Yasuo; Okada, Minoru; Fujita, Shigeo; Furuya, Toshio; Takenaka, Toichi; Inagaki, Osamu; Terai, Michio Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Journal of Medicinal Chemistry (1986), 29(12), 2504-11.
[2]	Arima, Hideki; Tamazawa, Kazuharu A process for the preparation of (4S)-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid (3S)-3-(1-benzyl)-3-pyrrolidinyl) ester 5-methyl ester as a vasodilator and antihypertensive Jpn. Kokai Tokkyo Koho (1987), JP 62174071 A 19870730.
[3]	Liau CS. Barnidipine: a new calcium channel blocker for hypertension treatment. Expert Rev Cardiovasc Ther. 2005 Mar;3(2):207-13.
[4]	Malhotra HS, Plosker GL Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.