103177-37-3 Pranlukast AKSci O046
 
 
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  O046    
Pranlukast, 98% (HPLC)
 
ONO 1078, 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
IDENTITY
CAS Number:103177-37-3
MDL Number:MFCD00864631
MF:C27H23N5O4
MW:481.5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Spectra:NMR, HPLC
Physical Form (at 20°C):White to off-white powder
Melting Point:231-244°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: upto 50nM
Application(s):Selective cysteinyl leukotriene receptor antagonist

REVIEW
 Pranlukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Pranlukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.

REFERENCES
[1]Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S: Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. Drug Metab Pharmacokinet. 2006 Apr;21(2):133-9.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319; H335; H413

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 28, 2022


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CATEGORIES
 APIs and Bioactives > Leukotrine Receptor Antagonists


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