103177-37-3 Pranlukast AKSci O046

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O046
Pranlukast, 98% (HPLC)

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ONO 1078, 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran

IDENTITY
CAS Number:	103177-37-3
MDL Number:	MFCD00864631
MF:	C27H23N5O4
MW:	481.5

SPECIFICATIONS & PROPERTIES
Purity:	98% (HPLC)
Spectra:	NMR, HPLC
Physical Form:	White to off-white powder
Melting Point:	231-244°C
Long-Term Storage:	Store long-term at -20°C

BIOLOGICAL INFO
Solubility:	DMSO: upto 50nM
Application(s):	Selective cysteinyl leukotriene receptor antagonist

REVIEW
Pranlukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Pranlukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airway edema, smooth muscle contraction, and enhanced secretion of thick, viscous mucus.

REFERENCES

[1]

Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S: Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma. Drug Metab Pharmacokinet. 2006 Apr;21(2):133-9.

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