75887-54-6 Arteether AKSci N732
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  N732    AKSci Reference Standard
, 98% (HPLC)
Dihydroartemisinin ethyl ether, NSC 665971

CAS Number:75887-54-6
MDL Number:MFCD00869355
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:80-82°C
Optical Rotation:+145 ~ +155° (c=1.0,in CHCl3)
Long-Term Storage:Store long-term at 2-8°C
Not hazardous material

Solubility:DMSO: 2 mg/mL, clear
Application(s):Derivative of Artemisinin and an antimalarial


 API Arteether, developed by Artecef, is the ethyl ether derivative of artemesinin. Arteether is a fast-acting blood schizonticide specifically indicated for the treatment of chloroquine-resistant Plasmodium falciparum malaria and cerebral malaria cases. It is a semi-synthetic derivative of artemisinin, a natural product of the Artemisia annua plant native to Asia. It is currently only used as a second line drug in severe cases of malaria.

[1]de Vries PJ, Dien TK. Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria Drugs. 1996 Dec;52(6):818-36.
[2] White NJ, Olliaro P. Artemisinin and derivatives in the treatment of uncomplicated malaria.
[3] Yeates RA. Artemotil Artecef. Curr Opin Investig Drugs. 2002 Apr;3(4):545-9.
[4] Kager PA. Three newly registered drugs in the Netherlands for the treatment and chemoprophylaxis of malaria: atovaquone-proguanil, artemether-lumefantrine and artemotil]. Ned Tijdschr Geneeskd. 2003 Feb 15;147(7):291-5.
[5] Van der Meersch H. Review of the use of artemisinin and its derivatives in the treatment of malaria]. J Pharm Belg. 2005;60(1):23-9.
[6] Kyu HH, Fernández E. Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review. Bull World Health Organ. 2009 Dec;87(12):896-904.



Signal Word

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 20, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.

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 APIs and Bioactives > Antimalarials