2447-54-3 Sanguinarine chloride AKSci M892
 
 
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  M892    
Sanguinarine chloride, 98% (HPLC)
 
Pseudochelerythrine
IDENTITY
CAS Number:2447-54-3
MDL Number:MFCD00012126
MF:C20H14NO4Cl·xH2O
MW:367.78 (anhy)
EINECS:219-503-3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:278-283°C
Density:1.34
Refractive Index:1.51
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in methanol; slightly soluble in water
Application(s):Na+/K+- and Mg2+-ATPase inhibitor

REVIEW
 Na+/K+-and Mg2+-ATPase inhibitor. Antimicrobial, anti-inflammatory and antioxidant properties. Induces apoptosis. Modulates the Bcl-2 family. Shows antiplaque activity in humans.

REFERENCES
[1]Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt: M.H. Han, et al.; Anticancer Drugs 18, 913 (2007).
[2] Metabolism of sanguinarine: the facts and the myths: Z. Dvorak & V. Simanek; Curr. Drug Metab. 8, 173 (2007), Review.
[3] Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 538 (2006).
[4] The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006).

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 13, 2025


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