82956-11-4 Nafamostat mesylate AKSci M731
 
 
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  M731    AKSci Reference Standard
Nafamostat mesylate
, 98%
 
4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate




IDENTITY
CAS Number:82956-11-4
MDL Number:MFCD00941430
MF:C19H17N5O2.2CH3SO3H
MW:539.58
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to off-white powder
Melting Point:259-263°C
Long-Term Storage:Store at room temperature
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >10 mg/mL; H2O: >10 mg/mL
Application(s):Anticoagulant

REVIEW

 Nafamostat mesylate is a highly effective tryptase (Ki=95.3 pM) inhibitor. The compound has the ability to promote synthesis of interferon-gamma, tumor necrosis factor-alpha, IL-12, and IL-18. Additionally, Nafamostat mesylate can induce production of intercellular adhesion molecules-1, B7.1, B7.2, CD40 and CD40 ligand in human blood mononuclear cells. Nafamostat mesylate is an anticoagulant and has been shown to decrease levels of plasma myeloperoxidase, and has also been used in ERCP pancreatitis studies. Nafamostat mesylate is an inhibitor of Factor X, Factor XII, granzyme A and KLK.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H361

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501


Current as of October 29, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Anticoagulants


PubChem