434-13-9 Lithocholic acid AKSci M622
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Lithocholic acid
, 98% (HPLC)
3a-Hydroxy-5b-cholan-24-oic acid
3a-Hydroxy-5b-cholanic acid
5b-Cholan-24-oic acid-3a-ol

CAS Number:434-13-9
MDL Number:MFCD00003682
Purity:98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:182-188°C
Optical Rotation:34° (c=1.5,C2H5OH)
Long-Term Storage:Store at room temperature


 Lithocholic acid is a steroidal bile acid that acts as a detergent to solubilize fats for absorption. It is produced by bacterial metabolism in the colon from chenodeoxycholic acid. It has been implicated in human and experimental animal carcinogenesis, with preliminary in vitro work indicating that it selectively kills neuroblastoma cells, while sparing normal neuronal cells and is cytotoxic to numerous other malignant cell types at physiologically relevant concentrations. Lithocholic acid and its acetate and propionate esters can activate the vitamin D receptor without raising calcium levels as much as vitamin D itself.

[1]Xu, Zhengbang; Li, Kaixi; Zhao, Huaming Synthesis of lithocholic acid by Huang-Min-Lon modification in the presence of crown ether Sichuan Daxue Xuebao, Ziran Kexueban (1992), 29(4), 527-9.
[2] Kozoni, V.; Tsioulias, G; Shiff, S; Rigas, B The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: Differential effect on apoptosis in the presence of a colon carcinogen. Carcinogenesis 2000, 21 (5): 999-1005.
[3] Hofmann AF.Detoxification of lithocholic acid, a toxic bile acid: relevance to drug hepatotoxicity. Drug Metab Rev. 2004 Oct;36(3-4):703-22.
[4] Goldberg, AA; Beach, A; Davies, GF; Harkness, TA; Leblanc, A; Titorenko, VI (2011). Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget 2011, 2 (10): 761-82.



Signal Word

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of August 21, 2019

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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


 APIs and Bioactives > Bile Acids, Chemotherapeutics