103-16-2 4-Benzyloxyphenol AKSci L650
 
 
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  L650    AKSci Bulk Reagent
4-Benzyloxyphenol
, 98% (GC)
 
Hydroquinone monobenzyl ether
Monobenzone
Benoquin




IDENTITY
CAS Number:103-16-2
MDL Number:MFCD00002333
MF:C13H12O2
MW:200.23
EINECS:203-083-3
BRN:1958305
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (GC)
Physical Form (at 20°C):Solid
Melting Point:117-124°C
Density:1.26
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 40mg/mL; H2O: <1mg/mL; EtOH: 40mg/mL
Application(s):Amelanotic Agent
Form:Free Base

REVIEW

 A compound used as a topical drug for medical depigmentation. The topical application of monobenzone in animals decreases the excretion of melanin from melanocytes. The same action is thought to be responsible for the depigmenting effect of the drug in humans. Monobenzone may cause destruction of melanocytes and permanent depigmentation.

REFERENCES
[1]van den Boorn JG, Melief CJ, Luiten RM (2011). Monobenzone-induced depigmentation: from enzymatic blockade to autoimmunity. Pigment Cell Melanoma Res. 24(4):673-9. PMID 21689385.
[2] van den Boorn JG, Picavet DI, van Swieten PF, van Veen HA, Konijnenberg D, van Veelen PA, van Capel T, Jong EC, Reits EA, Drijfhout JW, Bos JD, Melief CJ, Luiten RM (2011). Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy. J Invest Dermatol. 131(6):1240-51. PMID 21326294.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H317; H319

Precautionary Statements
P261; P272; P280; P302+P352; P333+P313; P363; P305+P351+P338; P337+P313; P503; P501


Current as of July 21, 2024


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CATEGORIES

 Aryl and Aliphatic Building Blocks > Alcohols, Ethers


PubChem