90776-58-2 (3S,4S)-4-[(R)-1-carboxyethyl]-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone AKSci K799
 
 
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  K799    
(3S,4S)-4-[(R)-1-carboxyethyl]-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone, 98%
 



IDENTITY
CAS Number:90776-58-2
MDL Number:MFCD00272297
MF:C14H27NO4Si
MW:301.45
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:146-155°C
Optical Rotation:-30.5° - -34° (c=1, MeOH)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 (3S,4S)-4-[(R)-1-carboxyethyl]-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone is a key intermediate toward the side chain of imipenem, a carbopenem antibiotic.

REFERENCES
[1]Shibata, Tomoyuki; Iino, Kimio; Tanaka, Teruo; Hashimoto, Toshihiko; Kameyama, Yukiko; Sugimura, Yukio Synthetic study of 1-substituted carbapenem antibiotics. Tetrahedron Letters (1985), 26(39), 4739-4742.
[2] Fuentes, Lelia M.; Shinkai, I.; Salzmann, T. N. Lewis acid mediated condensation of chiral imide enolates. A general approach to the synthesis of chiral carbapenem precursors Journal of the American Chemical Society (1986), 108(15), 4675-6.
[3] Iimori, Takamasa; Shibasaki, Masakatsu Simple, stereocontrolled synthesis of 1beta-methylcarbapenem antibiotics from 3(R)-hydroxybutyric acid Tetrahedron Letters (1986), 27(19), 2149-52.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
None

Hazard Statements
None

Precautionary Statements
Notavailable

Current as of October 15, 2024


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CATEGORIES
 APIs and Bioactives > Carbapenems, beta-Lactams


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