96829-58-2 Orlistat AKSci K744

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K744 AKSci Reference Standard
Orlistat, >98%, powder

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Tetrahydrolipstatin

N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester

(2S)-1-[(2S,3S)-3-Hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate

IDENTITY
CAS Number:	96829-58-2
MDL Number:	MFCD05662360
MF:	C29H53NO5
MW:	495.73
BRN:	3658031

SPECIFICATIONS & PROPERTIES
Purity:	>98%, powder
Spectra:	LCMS, Polarimetry
Physical Form:	White to off-white crystalline powder or powder
Melting Point:	42-47°C
Optical Rotation:	-33 - -36° (c=1, CHCl3)
Long-Term Storage:	Store long-term at 2-8°C

BIOLOGICAL INFO
Application(s):	Lipase inhibitor
Form:	Free base

REVIEW
Orlistat is a drug designed to treat obesity. Orlistat works by inhibiting gastric and pancreatic lipases, the enzymes that break down triglycerides in the intestine. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and are excreted undigested instead.

REFERENCES

[1]	Smith TJ, Crombie A, Sanders LF, Sigrist LD, Bathalon GP, McGraw S, Young AJ (2012). Efficacy of orlistat 60 mg on weight loss and body fat mass in US Army soldiers. J Acad Nutr Diet. 112(4):533-40. PMID 22717217.
[2]	Gelebart P, Zak Z, Anand M, Belch A, Lai R (2012). Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma. PLoS One. 7(4):e33738. PMID 22485149.

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