82034-46-6 Loteprednol etabonate AKSci K462
 
 
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  K462    
Loteprednol etabonate, 98% (HPLC)
 



IDENTITY
CAS Number:82034-46-6
MDL Number:MFCD00870765
MF:C24H31ClO7
MW:466.95
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:233-237°C
Optical Rotation:+38.0 to +42.0° (C=1, dioxane)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 93mg/mL; H2O: <1mg/mL; EtOH: 4mg/mL
Application(s):Glucocorticoid and mineralcorticoid receptors agonist
Form:Free Base

REVIEW
 A corticosteroid used in optometry and ophthalmology for treatment of inflammation of the eye due to allergies, chronic forms of keratitis, vernal keratoconjunctivitis, pingueculitis, and episcleritis.

REFERENCES
[1]Lu E, Fujimoto LT, Vejabul PA, Jew RL (2011). Steroid-induced ocular hypertension with loteprednol etabonate 0.2%--a case report. Optometry. 82(7):413-20. PMID 21543264.
[2] Wu WM, Bodor ET, Howes J, Bodor N (2012). The effects of delta1-cortienic acid on skin blanching, pharmacokinetics and stability of loteprednol etabonate. Pharmazie. 67(5):406-10. PMID 22764572.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of November 21, 2024


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CATEGORIES
 APIs and Bioactives > Steroid Hormones


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