7481-89-2 2',3'-Dideoxycytidine AKSci K278
 
 
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  K278    AKSci Reference Standard
2',3'-Dideoxycytidine, 98%
 
Zalcitabine
Hivid
Dideoxycytidine
IDENTITY
CAS Number:7481-89-2
MDL Number:MFCD00012188
MF:C9H13N3O3
MW:211.22
BRN:654956
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:214-219°C
Optical Rotation:90° (c=0.5,in H2O)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 42mg/mL; H2O: 42mg/mL; EtOH: <1mg/mL
Application(s):Nucleoside analog HIV reverse transcriptase inhibitor (NARTI)
Form:Free Base

REVIEW
 Zalcitabine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Within cells, zalcitabine is converted to its active metabolite, dideoxycytidine 5'-triphosphate (ddCTP), by the sequential action of cellular enzymes. ddCTP interferes with viral RNA-directed DNA polymerase (reverse transcriptase) by competing for utilization of the natural substrate deoxycytidine 5'-triphosphate (dCTP), as well as incorpating into viral DNA. Due to it's lack of a 3'-OH group, the formation of a 5' to 3' phosphodiester linkage that is necessary for DNA chain elongation is inhibited, thus leading to the termination of viral DNA growth.

REFERENCES
[1]Shelton MJ, O'Donnell AM, Morse GD: Zalcitabine. Ann Pharmacother. 1993 Apr;27(4):480-9.
[2] Devineni D, Gallo JM: Zalcitabine. Clinical pharmacokinetics and efficacy. Clin Pharmacokinet. 1995 May;28(5):351-60.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H351

Precautionary Statements
P201; P202; P281; P405; P503; P501

Current as of November 21, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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WARNING: Attention California residents: This product can expose you to chemicals including 2',3'-Dideoxycytidine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Antivirals, Antiretrovirals, NRTIs
 Nucleobases > Nucleosides
 Nucleobases > Nucleosides


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