66532-86-3 Propacetamol HCl AKSci K088
 
 
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  K088    AKSci Bulk Reagent
Propacetamol HCl, 98% (HPLC)
 
4-Acetamidophenyl 2-(diethylamino)acetate hydrochloride
IDENTITY
CAS Number:66532-86-3
MDL Number:MFCD00941392
MF:C14H21ClN2O3
MW:300.78
EINECS:266-391-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:226-235°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O
Form:HCl salt

REVIEW
 Propacetamol is a prodrug form of paracetamol which is formed by esterification of paracetamol with the carboxylic acid diethylglycine making it more water-soluble. It is used in post-operative care and is delivered by I.V. It is also given if the patient is unable to take oral or rectally delivered paracetamol and non-steroidal anti-inflammatory drugs are contraindicated.

REFERENCES
[1]Bannwarth B, Netter P, Lapicque F, Gillet P, Péré P, Boccard E, Royer RJ, Gaucher A. Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. Br J Clin Pharmacol. 1992 Jul;34(1):79-81.
[2] Binhas M, Decailliot F, Rezaiguia-Delclaux S, Suen P, Dumerat M, François V, Combes X, Duvaldestin P. Comparative effect of intraoperative propacetamol versus placebo on morphine consumption after elective reduction mammoplasty under remifentanil-based anesthesia: a randomized control trial [ISRCTN71723173]. BMC Anesthesiol. 2004 Sep 14;4(1):6.
[3] Moller PL, Sindet-Pedersen S, Petersen CT, Juhl GI, Dillenschneider A, Skoglund LA. Onset of acetaminophen analgesia: comparison of oral and intravenous routes after third molar surgery. Br J Anaesth. 2005 May;94(5):642-8. Epub 2005 Mar 24.
[4] Viel E, Langlade A, Osman M, Bilbault P, Eledjam JJ. Propacetamol: from basic action to clinical utilization]. Ann Fr Anesth Reanim. 1999 Mar;18(3):332-40.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 28, 2025


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All batches backed with full quality assurance.
⚠️
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These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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CATEGORIES
 APIs and Bioactives > Analgesics


PubChem
  @PubMed