REVIEW Bisbentiamine is an O-benzoyl thiamine disulfide or vitamin B1 disulfide derivative. Thiamine derivatives and thiamine-dependent enzymes are present in all cells of the body, thus a thiamine deficiency would seem to adversely affect all of the organ systems. Lipid-soluble thiamine precursors such as Bisbentiamine have a much higher bioavailability than genuine thiamine and therefore are more suitable for therapeutic purposes. It is also used as a dietary supplement.
REFERENCES
[1]
Utsumi, Isamu; Harada, Kiyoshi; Kobayashi, Hiroshi; Kono, Keiichi; Yasuda, Kozo; Kondo, Yohko; Hirao, Hiroko. Thiamine disulfide. II. Biological properties of O-benzoylthiamine disulfide. Journal of Vitaminology. (1962) 8: 213-19.
[2]
Utsumi, Isamu; Harada, Kiyoshi; Hirao, Hiroko; Kotera, Keishi. Thiamine disulfide. I. Physicochemical properties of O-benzoylthiamine disulfide. Journal of Vitaminology. (1962) 8: 206-12.
[3]
Aoki, Koji; Suzui, Akio. Preparation of O-acylthiamine disulfides. Jpn. Kokai Tokkyo Koho. (1990) JP 02282372 A 19901119.
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