65002-17-7 Bucillamine AKSci J99619
 
 
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  J99619    
Bucillamine, 95%
 
Tiobutarit
Rimatil
Thiobutarit
IDENTITY
CAS Number:65002-17-7
MDL Number:MFCD00867570
MF:C7H13NO3S2
MW:223.31
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:139-143°C
Optical Rotation:+29.0° - +35.0° (c=1, EtOH)
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Anti-Inflammatory Agent; Antioxidant
Form:Free Base

REVIEW
 Bucillamine is an antirheumatic agent developed from tiopronin and structurally related to penicillamine. It has been used in Rheumatoid Arthritis and is reported to be an immunomodulator.

REFERENCES
[1]Isozaki T; Kimura M; Ikegaya N; Arai T; Fujigaki Y; Hishida A; Kaneko E. Bucillamine (a new therapeutic agent for rheumatoid arthritis) induced nephrotic syndrome: a report of two cases and review of the literature. The Clinical Investigator. (1992) 70(11): 1036-42.
[2] Matsuno H; Sugiyama E; Muraguchi A; Nezuka T; Kubo T; Matsuura K; Tsuji H. Pharmacological effects of SA96 (bucillamine) and its metabolites as immunomodulating drugs--the disulfide structure of SA-96 metabolites plays a critical role in the pharmacological action of the drug. International Journal of Immunopharmacology. (1998) 20(6): 295-304.
[3] Tsuji, Fumio; Aono, Hiroyuki; Okamoto, Masahiro; Sasano, Minoru. Bucillamine, a unique anti-rheumatic drug. Current Topics in Pharmacology. (2006) 10(1): 43-46.
[4] Fujita, Tadashi; Sakai, Osaka; Oya, Masayuki; Takashina, Hideo; Iso, Tadashi Cysteine derivatives Ger. Offen. (1977), DE 2709820 A1 19770915.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 18, 2024


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