105628-07-7 Fasudil hydrochloride AKSci J99419

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J99419
Fasudil hydrochloride, 95%, for synthesis

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Fasudil

5-(1-Homopiperazinyl)sulfonylisoquinoline hydrochloride

1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride

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Structure N/A

IDENTITY
CAS Number:	105628-07-7
MDL Number:	MFCD00943198
MF:	C14H18ClN3O2S
MW:	327.83
BRN:	5466340

SPECIFICATIONS & PROPERTIES
Purity:	95%, for synthesis
Physical Form:	White to almost white powder or crystals
Melting Point:	208-215°C
Long-Term Storage:	Store at room temperature

BIOLOGICAL INFO
Solubility:	Soluble in water and methanol; Very slightly soluble in ethanol; Insoluble in ether
Application(s):	Rho-kinase inhibitor and vasodilator

REVIEW
RhoA/Rho kinase(ROCK) inhibitor that plays an important role in mediating vasoconstriction and vascular remodeling in the pathogenesis of PH. ROCK induces vasoconstriction by phosphorylating the myosin-binding subunit of myosin light chain (MLC) phosphatase, thus decreasing MLC phosphatase activity and enhancing vascular smooth muscle contraction.

REFERENCES

[1]

Nagumo, H., Sasaki, Y., Ono, Y., Okamato, H., Seto, M., and Takuwa, Y. (2000). Rho kinase inhibitor HA-1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. American Journal of Physiology. 278: C57-C65.

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