REVIEW (3S,4S)-4-[(R)-1-carboxyethyl]-3-[(R)-1-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone is a key intermediate toward the side chain of imipenem, a carbopenem antibiotic.
Fuentes, Lelia M.; Shinkai, I.; Salzmann, T. N. Lewis acid mediated condensation of chiral imide enolates. A general approach to the synthesis of chiral carbapenem precursors Journal of the American Chemical Society (1986), 108(15), 4675-6.
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Iimori, Takamasa; Shibasaki, Masakatsu Simple, stereocontrolled synthesis of 1beta-methylcarbapenem antibiotics from 3(R)-hydroxybutyric acid Tetrahedron Letters (1986), 27(19), 2149-52.
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