106463-17-6 Tamsulosin HCl AKSci J99186

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J99186
Tamsulosin HCl, 95%

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5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

Harnal

Flomax

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Structure N/A

IDENTITY
CAS Number:	106463-17-6
MDL Number:	MFCD00922997
MF:	C20H29ClN2O5S
MW:	444.97

SPECIFICATIONS & PROPERTIES
Purity:	95%
Physical Form:	White to light yellow crystalline powder
Melting Point:	227-233°C
Optical Rotation:	-17.5° - -20.5° (c=1, H2O)
Long-Term Storage:	Store at room temperature

BIOLOGICAL INFO
Solubility:	DMSO: >10mg/mL
Application(s):	Selective antagonist at alpha-1A and alpha-1B-adrenoceptors
Form:	HCl salt

REVIEW
Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men.

REFERENCES

[1]	Dunn CJ, Matheson A, Faulds DM: Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms. Drugs Aging. 2002;19(2):135-61.
[2]	Lyseng-Williamson KA, Jarvis B, Wagstaff AJ: Tamsulosin: an update of its role in the management of lower urinary tract symptoms. Drugs. 2002;62(1):135-67.
[3]	Wilt TJ, Mac Donald R, Rutks I: Tamsulosin for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2003;(1):CD002081.

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