64-86-8 Colchicine AKSci J98980
 
 
Loading Please Wait...
  J98980    AKSci Bulk Reagent
Colchicine, 95%
 
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
IDENTITY
CAS Number:64-86-8
MDL Number:MFCD00078484
MF:C22H25NO6
MW:399.44
EINECS:200-598-5
BRN:2228813
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:154-161°C (dec)
Optical Rotation:-230° ~ -245° (c=1, Ethanol)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN1544
Hazard Class:6.1; Poison
Packing Group:I
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

REVIEW
 Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

REFERENCES
[1]Hwang, D.; Wang, J.; Li, W.; Miller, D. D. Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents. ACS Med. Chem. Lett. 2015, 6 (9), 993-997.
[2] Kuroiwa, K.; Ishii, H.; Matsuno, K.; Asai, A.; Suzuki, Y. Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents. ACS Med. Chem. Lett. 2015, 6 (3), 287-291.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H300+H330; H318; H340

Precautionary Statements
P201; P202; P260; P264; P270; P271; P280; P284; P301+P310; P304+P340; P305+P351+P338; P310; P320; P330; P403+P233; P405; P501

Current as of April 25, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Colchicine, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Natural Products


PubChem