64-86-8 Colchicine AKSci J98980
 
 
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  J98980    
Colchicine
, 95%
 
(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide




IDENTITY
CAS Number:64-86-8
MDL Number:MFCD00078484
MF:C22H25NO6
MW:399.44
EINECS:200-598-5
BRN:2228813
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form:White to light yellow scales or powder
Melting Point:154-161°C (dec)
Optical Rotation:-230° ~ -245° (c=1, Ethanol)
Long-Term Storage:Store at room temperature
HAZARDOUS MATERIALS INFORMATION
UN #:UN1544
Hazard Class:6.1; Poison
Packing Group:I
A hazmat fee may apply, depending on the amount ordered.

REVIEW

 Antimitotic agent that disrupts microtubules by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

REFERENCES
[1]Hwang, D.; Wang, J.; Li, W.; Miller, D. D. Structural Optimization of Indole Derivatives Acting at Colchicine Binding Site as Potential Anticancer Agents. ACS Med. Chem. Lett. 2015, 6 (9), 993-997.
[2] Kuroiwa, K.; Ishii, H.; Matsuno, K.; Asai, A.; Suzuki, Y. Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents. ACS Med. Chem. Lett. 2015, 6 (3), 287-291.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H300+H330; H318; H340

Precautionary Statements
P201; P202; P260; P264; P270; P271; P280; P284; P301+P310; P304+P340; P305+P351+P338; P310; P320; P330; P403+P233; P405; P501


Current as of June 16, 2021


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.

WARNING: Attention California residents: This product can expose you to chemicals including Colchicine, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.


CATEGORIES

 APIs and Bioactives > Natural Products


PubChem