144481-98-1 Landiolol HCl AKSci J98964
 
 
Loading Please Wait...
  J98964    
Landiolol HCl, 95%
 



IDENTITY
CAS Number:144481-98-1
MDL Number:MFCD01937430
MF:C25H39N3O8.HCl
MW:546.05
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:122-127°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Short-acting beta blocker

REVIEW
 Landiolol acts as a highly cardioselective, ultra-short-acting beta blocker used as an anti-arrhythmic agent. It was developed for application in the emergency treatment of tachycardia and better control of heart rate in surgery. It is approximately nine times more potent in beta-blocking activity in vivo and eight times more cardioselective in vitro than esmolol. It has a short duration of activity, enabling rapid recovery after cessation of administration if side effects occur. It can be used safely in patients suffering from acute heart disease.

REFERENCES
[1]Iguchi, Yoichi; Wakatsuka, Hirohisa Preparation of (2,2-dimethyl-1,3-dioxolan-4S-yl)methyl 3-[4-(2S-hydroxy-3-(2-morpholinocarbonylaminoethyl)aminopropoxyphenyl]propionate hydrochloride as beta1-adrenergic antagonist and its intermediate Jpn. Kokai Tokkyo Koho (1993), JP 05306281 A 19931119.
[2] Iguchi, Sadahiko; Iwamura, Hiroyuki; Nishizaki, Minoru; Hayashi, Akio; Senokuchi, Kazuhiko; Kobayashi, Kaoru; Sakaki, Katsuhito; Hachiya, Katsutoshi; Ichioka, Yumiko; Kawamura, Masanori Development of a highly cardioselective ultra short-acting beta-blocker, ONO-1101 Chemical & Pharmaceutical Bulletin (1992), 40(6), 1462-9.
[3] Yoshiya I.Landiolol hydrochloride, a new sympathetic beta blocker. Masui. 1998 Dec;47 Suppl:S126-32.
[4] Ogata J, Okamoto T, Minami K.Landiolol for the treatment of tachyarrhythmia associated with atrial fibrillation. Can J Anaesth. 2003 Aug-Sep;50(7):753.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 25, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Beta Blockers


PubChem