63659-19-8 Betaxolol hydrochloride AKSci J98892
 
 
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  J98892    
Betaxolol hydrochloride, 95%
 



IDENTITY
CAS Number:63659-19-8
MDL Number:MFCD00242959
MF:C18H30ClNO3
MW:343.89
EINECS:264-384-3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:114-118°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: soluble 36mg/mL
Application(s):beta-1 receptors

REVIEW
 Betaxolol hydrochloride is a racemic, selective beta1 receptor blocker used in the treatment of hypertension and glaucoma. It typically has fewer systemic side effects than non-selective beta-blockers, for example, not causing bronchospasm (mediated by beta2 receptors) as timolol may. Betaxolol also shows greater affininty for beta1 receptors than metoprolol. In addition to its effect on the heart, betaxolol reduces intraocular pressure by reducing the production of the aqueous humor liquid within the eye. This reduces the risk of damage to the optic nerve and loss of vision in patients with elevated intraocular pressure due to glaucoma.

REFERENCES
[1]Ippolito, Robert Maurice; Vigmond, Stephen Process for the preparation of betaxolol and related 1-[4-[2-(cycloalkylalkoxy)ethyl]phenoxy]-3-(alkylamino)-2-propanol pharmaceuticals Brit. UK Pat. Appl. (1987), GB 2187190 A 19870903.
[2] Ippolito, Robert M.; Vigmond, Stephen Process for preparing phenoxypropanolamines, e.g. betaxolol, via oxazolidine intermediates U.S. (1988), US 4760182 A 19880726.
[3] Bianchetti, G.; Blatrix, C.; Gomeni, R.; Kilborn, J. R.; Larribaud, J.; Luecker, P. W.; Morselli, P. L.; Thebault, J. J.; Trocherie, S. Pharmacokinetics of the new β-adrenoceptor blocker SL 75212 in man after repeated oral administration British Journal of Clinical Pharmacology (1979), 8(4), 408P.
[4] Bianchetti, G.; Blatrix, C.; Gomeni, R.; Kilborn, J. R.; Larribaud, J.; Luecker, P. W.; Thebault, J. J.; Trocherie, S.; Morselli, P. L. Pharmacokinetics of the new β-adrenoceptor blocking agent betaxolol (SL 75212) in man after repeated oral administration Arzneimittel-Forschung (1980), 30(11), 1912-16.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of April 19, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Beta Blocker


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