REVIEW Tilorone, a fluorenone derivative, is the first recognized synthetic, small molecular weight compound that is an orally-active interferon inducer. Developed in Russia, it is used as an antiviral drug. It has also been shown to be a DNA intercalator.
REFERENCES
[1]
Stringfellow DA, Glasgow LA. Tilorone hydrochloride: an oral interferon-inducing agent. Antimicrob Agents Chemother. 1972 Aug;2(2):73-8.
[2]
Burke H M; Joullie M M New synthetic routes to tilorone dihydrochloride and some of its analogues Journal of medicinal chemistry (1978), 21(10), 1084-6.
[3]
Zschiesche W; Fahlbusch B; Schumann I; Tonew E Induction of cytokines by tilorone hydrochloride Agents andactions (1978), 8(5), 515-22.
[4]
Megel H; Raychaudhuri A; Shemano I; Beaver T H; Thomas L L The anti-inflammatory actions of tilorone hydrochloride Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) (1975), 149(1), 89-93.
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