27591-69-1 Tilorone 2HCl AKSci J98643
 
 
Loading Please Wait...
  J98643    
Tilorone 2HCl
, 95%
 
2,7-Bis[2-(diethylamino)ethoxy]-9-fluorenone dihydrochloride

Structure N/A

IDENTITY
CAS Number:27591-69-1
MDL Number:MFCD00134071
MF:C25H36Cl2N2O3
MW:483.47
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:Yellow to orange powder
Melting Point:227-241°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: insoluble; H2O: 5mg/mL; MeOH: 5mg/mL
Form:2HCl salt

REVIEW

 Tilorone, a fluorenone derivative, is the first recognized synthetic, small molecular weight compound that is an orally-active interferon inducer. Developed in Russia, it is used as an antiviral drug. It has also been shown to be a DNA intercalator.

REFERENCES
[1]Stringfellow DA, Glasgow LA. Tilorone hydrochloride: an oral interferon-inducing agent. Antimicrob Agents Chemother. 1972 Aug;2(2):73-8.
[2] Burke H M; Joullie M M New synthetic routes to tilorone dihydrochloride and some of its analogues Journal of medicinal chemistry (1978), 21(10), 1084-6.
[3] Zschiesche W; Fahlbusch B; Schumann I; Tonew E Induction of cytokines by tilorone hydrochloride Agents andactions (1978), 8(5), 515-22.
[4] Megel H; Raychaudhuri A; Shemano I; Beaver T H; Thomas L L The anti-inflammatory actions of tilorone hydrochloride Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) (1975), 149(1), 89-93.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332; H315; H319; H335; H351

Precautionary Statements
P201; P202; P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P308+P313; P322; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 20, 2019


Download SDS

For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antivirals


PubChem
  @PubMed