56211-40-6 Torsemide AKSci J98616
 
 
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  J98616    
Torsemide, 95%
 
N-[[(1-Methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]-3-pyridinesulfonamide
Demadex
IDENTITY
CAS Number:56211-40-6
MDL Number:MFCD00866166
MF:C16H20N4O3S
MW:348.42
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:160-165°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 18mg/mL; H2O: insoluble
Application(s):Sodium Potassium Chloride Symporter Inhibitor
Form:Free Base

REVIEW
 A pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension.

REFERENCES
[1]TORAFIC Investigators Group (2012). Effects of prolonged-release torasemide versus furosemide on myocardial fibrosis in hypertensive patients with chronic heart failure: a randomized, blinded-end point, active-controlled study. Clin Ther. 33(9):1204-1213.e3. PMID 21906812.
[2] Peddle GD, Singletary GE, Reynolds CA, Trafny DJ, Machen MC, Oyama MA (2012). Effect of torsemide and furosemide on clinical, laboratory, radiographic and quality of life variables in dogs with heart failure secondary to mitral valve disease. J Vet Cardiol. 14(1):253-9. PMID 22364690.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H319

Precautionary Statements
P264; P280; P305+P351+P338; P337+P313

Current as of April 20, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Diuretics


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