269055-15-4 Etravirine AKSci J97992
 
 
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  J97992    
Etravirine
, 95%
 
TMC125




IDENTITY
CAS Number:269055-15-4
MDL Number:MFCD09837879
MF:C20H15BrN6O
MW:435.28
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:262-265°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Non-nucleoside reverse transcriptase inhibitor (NNRTI)

REVIEW

 Etravirine is a second-generation non-nucleoside reverse transcriptase inhibitor (NNRTI), designed to be active against HIV with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs, mutation K103N for efavirenz and Y181C for nevirapine.

REFERENCES
[1]Minuto, Joshua J.; Haubrich, Richard. Etravirine: a second-generation NNRTI for treatment-experienced adults with resistant HIV-1 infection. Future HIV Therapy. (2008) 2(6): 525-537.
[2] Seminari, E.; Castagna, A.; Lazzarin, A. Etravirine for the treatment of HIV infection. Expert Review of Anti-Infective Therapy. (2008) 6(4): 427-433.
[3] Scholler-Gyure, Monika; Kakuda, Thomas N.; Raoof, Araz; De Smedt, Goedele; Hoetelmans, Richard M. W. Clinical pharmacokinetics and pharmacodynamics of etravirine. Clinical Pharmacokinetics. (2009) 48(9): 561-574.
[4] De Corte, Bart; De Jonge, Marc Rene; Heeres, Jan; Ho, Chih Yung; Janssen, Paul Adriaan Jan; Kavash, Robert W.; Koymans, Lucien Maria Henricus; Kukla, Michael Joseph; Ludovici, Donald William; Van Aken, Koen Jeanne AlfonsPreparation of arylaminopyrimidines as inhibitors of HIV replication. PCT Int. Appl. (2000), WO 2000027825 A1 20000518.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 15, 2024


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CATEGORIES

 APIs and Bioactives > Antivirals;NNRTIs


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