REVIEW Key intermediate used in the synthesis of pazopanib hydrochloride, a potent and selective multi-targeted receptor tyrosine kinase inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-alpha/beta, and c-kit that blocks tumor growth and inhibits angiogenesis.
REFERENCES
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Philip A. Harris , Amogh Boloor, Mui Cheung , Rakesh KumarRenae M. Crosby, Ronda G. Davis-Ward, Andrea H. Epperly, Kevin W. Hinkle, Robert N. Hunter , III, Jennifer H. Johnson, Victoria B. Knick, Christopher P. Laudeman, Deirdre K. Luttrell, Robert A. Mook , Robert T. Nolte, Sharon K. Rudolph , Jerzy R. Szewczyk , Anne T. Truesdale , James M. Veal , Liping Wang and Jeffrey A. Stafford Disocovery of 5-[[4-[(2,3-Dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a Novel and Potent Vascular Endothelial Growth Factor Receptor Inhibitor. Journal of Medicinal Chemistry (2008), 51(15), 4632-4640.
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Mei, Yi Cheng; Yang, Bao Wei; Chen, Wei; Huang, Dan Dan; Li, Ying; Deng, Xin; Liu, Bao Ming; Wang, Jing Jie; Qian, Hai; Huang, Wen Long; A novel practical synthesis of pazopanib: an anticancer drug, Letters in Organic Chemistry (2012), 9(4), 276-279.
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