1041434-82-5 Peramivir trihydrate AKSci J97027
 
 
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  J97027    
Peramivir trihydrate, 95%
 
(1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-guanidino-2-hydroxycyclopentanecarboxylic acid trihydrate, MK-2866
IDENTITY
CAS Number:1041434-82-5
MDL Number:MFCD22417093
MF:C15H34N4O7
MW:382.45
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:257-262°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Form:Hydrate

REVIEW
 Peramivir, a transition state analog inhibitor, is a neuraminidase inhibitor antiviral drug for the treatment of influenza.

REFERENCES
[1]Keller, Egbert; Kraemer, Volker Crystal structure of the trihydrate of the neuraminidase inhibitor C15H28N4O4 (peramivir), a potential influenza A/B and avian-influenza (H5N1) drug Zeitschrift fuer Naturforschung, B: Chemical Sciences (2007), 62(8), 983-987.
[2] Li, Song; Zhong, Wu; Zheng, Zhibing; Zhou, Xinbo; Xiao, Junhai; Xie, Yunde; Wang, Lili; Li, Xingzhou; Zhao, Guoming; Wang, Xiaokui; et al Preparation of (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-1-cyclopentanecarboxylic acid hydrates as neuraminidase inhibitors for treatment of influenza PCT Int. Appl. (2009), WO 2009021404 A1 20090219.
[3] Chen, Xiaoyong; Li, Peijie; Liang, Jie Process for preparation of peramivir Faming Zhuanli Shenqing (2012), CN 102633686 A 20120815.
[4] Barnard DL. RWJ-270201 BioCryst Pharmaceuticals/Johnson & Johnson. Curr Opin Investig Drugs. 2000 Dec;1(4):421-4.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
B630Peramivir
Y0248Peramivir trihydrate

Current as of January 28, 2025


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CATEGORIES
 APIs and Bioactives > Antivirals, Influenza


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