REVIEW Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.
Bacher I, Wu B, Shytle DR, George TP (November 2009). Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opinion on Pharmacotherapy 10 (16): 2709-21. doi:10.1517/14656560903329102. PMID 19874251.
Lippiello PM, Beaver JS, Gatto GJ, et al (2008). TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther 14 (4): 266-77. doi:10.1111/j.1755-5949.2008.00054.x. PMID 19040552.
Shytle RD, Penny E, Silver AA, Goldman J, Sanberg PR (July 2002). Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens 16 (7): 453-7. doi:10.1038/sj.jhh.1001416. PMID 12080428.
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