826-39-1 Mecamylamine HCl AKSci J96206
 
 
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  J96206    
Mecamylamine HCl, 95%
 
2-(Methylamino)isocamphane hydrochloride
IDENTITY
CAS Number:826-39-1
MDL Number:MFCD00151462
MF:C11H22ClN
MW:203.75
EINECS:212-555-8
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:266-267°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:Ethanol: 122 mg/mL; H2O: 47 mg/mL; isopropanol: 476 mg/mL; glycerol: 95 mg/mL
Application(s):Nicotinic antagonist
Form:HCl salt

REVIEW
 Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.

REFERENCES
[1]Bacher I, Wu B, Shytle DR, George TP (November 2009). Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opinion on Pharmacotherapy 10 (16): 2709-21. doi:10.1517/14656560903329102. PMID 19874251.
[2] Lippiello PM, Beaver JS, Gatto GJ, et al (2008). TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther 14 (4): 266-77. doi:10.1111/j.1755-5949.2008.00054.x. PMID 19040552.
[3] Shytle RD, Penny E, Silver AA, Goldman J, Sanberg PR (July 2002). Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens 16 (7): 453-7. doi:10.1038/sj.jhh.1001416. PMID 12080428.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P310; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 18, 2025


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CATEGORIES
 APIs and Bioactives > AChR Antagonists


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