826-39-1 Mecamylamine HCl AKSci J96206
 
 
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  J96206    
Mecamylamine HCl
, 95%
 
2-(Methylamino)isocamphane hydrochloride

Structure N/A

IDENTITY
CAS Number:826-39-1
MDL Number:MFCD00151462
MF:C11H22ClN
MW:203.75
EINECS:212-555-8
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White to almost white crystalline powder
Melting Point:266-267°C
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Solubility:Ethanol: 122 mg/mL; H2O: 47 mg/mL; isopropanol: 476 mg/mL; glycerol: 95 mg/mL
Application(s):Nicotinic antagonist
Form:HCl salt

REVIEW

 Mecamylamine is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Mecamylamine is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.

REFERENCES
[1]Bacher I, Wu B, Shytle DR, George TP (November 2009). Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opinion on Pharmacotherapy 10 (16): 2709-21. doi:10.1517/14656560903329102. PMID 19874251.
[2] Lippiello PM, Beaver JS, Gatto GJ, et al (2008). TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity. CNS Neurosci Ther 14 (4): 266-77. doi:10.1111/j.1755-5949.2008.00054.x. PMID 19040552.
[3] Shytle RD, Penny E, Silver AA, Goldman J, Sanberg PR (July 2002). Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens 16 (7): 453-7. doi:10.1038/sj.jhh.1001416. PMID 12080428.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P310; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of March 22, 2019


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CATEGORIES

 APIs and Bioactives > AChR Antagonists


PubChem