104239-97-6 4-Aza-5alpha-androstan-1-ene-3-one-17beta-carboxylic acid AKSci J96084

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J96084
4-Aza-5alpha-androstan-1-ene-3-one-17beta-carboxylic acid, 95%

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3-Oxo-4-aza-5α

-androst-1-ene-17-carboxylic acid

Structure N/A

IDENTITY
CAS Number:	104239-97-6
MDL Number:	MFCD08063794
MF:	C19H27NO3
MW:	317.43

SPECIFICATIONS & PROPERTIES
Purity:	95%
Physical Form:	Off-white to yellow-brown powder
Melting Point:	>250°C
Long-Term Storage:	Store at room temperature
UN #:	Not hazmat

REVIEW
4-Aza-5alpha-androstan-1-ene-3-one-17beta-carboxylic acid or Dutasteride (trademark name Avodart, manufactured by GlaxoSmithKline) is a dual (type 1 and 2) 5-alpha reductase inhibitor that inhibits conversion of testosterone to dihydrotestosterone (DHT). It is used for benign prostatic hyperplasia and its chemopreventation, however increases the risk of erectile dysfunction and decrease sexual desire.

REFERENCES

[1]	Zhao, Shuang; Bioorganic & Medicinal Chemistry Letters 2011, V21(11), P3439-3442
[2]	Satyanarayana, Komati; Organic Process Research & Development 2007, V11(5), P842-845
[3]	Zhang, Kui-Ping; Journal of Chinese Pharmaceutical Sciences 2007, V16(3), P233-235
[4]	Rasmusson, Gary H.; Reynolds, Glenn F.; Steinberg, Nathan G.; Walton, Edward; Patel, Gool F.; Liang, Tehming; Cascieri, Margaret A.; Cheung, Anne H.; Brooks, Jerry R.; Berman, Charles; Azasteroids: structure-activity relationships for inhibition of 5alpha-reductase and of androgen receptor binding. Journal of Medicinal Chemistry (1986), 29(11), 2298-315.