97240-79-4 Topiramate AKSci J95743
 
 
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  J95743    
Topiramate
, 95%
 
2,3:4,5-Bis-O-(1-methylethylidene)-36-D-fructo-pyranose sulfamate
Topamax

Structure N/A

IDENTITY
CAS Number:97240-79-4
MDL Number:MFCD00865320
MF:C12H21NO8S
MW:339.36
BRN:5988957
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White to light yellow powder
Melting Point:110-128°C
Optical Rotation:-33° - -29° (c=1,MeOH)
Long-Term Storage:Store long-term at -20°C

BIOLOGICAL INFO
Solubility:DMSO: 44mg/mL; H2O: <1mg/mL; EtOH: 68mg/mL
Application(s):Carbonic Anhydrase inhibitor
Form:Free Base

REVIEW

 An anticonvulsant (antiepilepsy) drug. The exact mechanism of action is unknown. The properties that may contribute to topiramate's antiepileptic and antimigraine efficacy include a blockage of voltage-dependent sodium channels, an augmentation of gamma-aminobutyrate acid activity at some subtypes of the GABA- A receptors, antagonism of AMPA/kainate subtype of the glutamate receptor, and inhibition of the carbonic anhydrase enzyme, particularly isozymes II and IV .

REFERENCES
[1]Caricilli AM, Penteado E, de Abreu LL, Quaresma PG, Santos AC, Guadagnini D, Razolli D, Mittestainer FC, Carvalheira JB, Velloso LA, Saad MJ, Prada PO (2012). Topiramate treatment improves hypothalamic insulin and leptin signaling and action and reduces obesity in mice. Endocrinology. 153(9):4401-11. PMID 22822160.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of March 26, 2019


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CATEGORIES

 APIs and Bioactives > Anticonvulsants, Carbonic Anhydrase Inhibitors


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