69388-84-7 Sulbactam sodium AKSci J95709
 
 
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  J95709    AKSci Bulk Reagent
Sulbactam sodium
, 95%
 



IDENTITY
CAS Number:69388-84-7
MDL Number:MFCD01750374
MF:C8H10NNaO5S
MW:255.22
EINECS:273-984-4
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:262-267°C
Optical Rotation:+217 ~ +225° (c=1, H2O)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Sulbactam sodium salt is a water soluble beta-lactamase inhibitor with very weak antibacterial action. This drug is given in combination with beta-lactam antibiotics to prevent destruction of the beta-lactam antibiotics by inhibiting beta-lactamases, thus extending their spectrum activity. Combinations of sulbactam with beta-lactam antibiotics have been used successfully for the therapy of infections caused by organisms resistant to the antibiotic alone. Sulbactam is an irreversible inhibitor of beta-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.

REFERENCES
[1]Barth, Wayne Ernest; Penicillanic acid 1,1-dioxides Ger. Offen. (1978), DE 2824535 A1 19781214.
[2] Barth, Wayne E., Penicillanic acid 1,1-dioxides as beta-lactamase inhibitors. U.S. (1980), US 4234579 A 19801118.
[3] Sjövall J, Huitfeldt B, Magni L, Nord CE. Effect of beta-lactam prodrugs on human intestinal microflora. Scand J Infect Dis Suppl. 1986;49:73-84.
[4] Foulds G. Pharmacokinetics of sulbactam/ampicillin in humans: a review. Rev Infect Dis. 1986 Nov-Dec;8 Suppl 5:S503-11.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of October 16, 2024


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CATEGORIES

 APIs and Bioactives > Antibacterials


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