75706-12-6 Leflunomide AKSci J95108
 
 
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  J95108    
Leflunomide
, 95%
 
5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide)




IDENTITY
CAS Number:75706-12-6
MDL Number:MFCD00867593
MF:C12H9F3N2O2
MW:270.21
BRN:4323174
SPECIFICATIONS & PROPERTIES
Purity:95%
Physical Form:White or almost white crystalline powder
Melting Point:164-170°C
Density:1.392
Refractive Index:1.541
Long-Term Storage:Store long-term at 2-8°C
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III

BIOLOGICAL INFO
Application(s):An inhibitor of Cox-2 and tyrosine kinase

REVIEW

 Leflunomide is an immunosuppressive drug that inhibits T and B cell responses. Leflunomide is an inhibitor of Cox-2, of tyrosine phosphorylation (tyrosine kinase), of DHODH (dihydroorotate dehydrogenase), an enzyme for de novo pyrimidine synthesis, and of TNF-dependent NF-κB activation. The physiological activity of leflunomide is attributed mainly to its metabolite.

REFERENCES
[1]Bartlett, R.R., et al. 1985. Int. J. Immunopharmacol. 7: 7-18. PMID: 3873420
[2] Bartlett, R.R., et al. 1991. Agents Actions 32: 10-21. PMID: 2058454
[3] Mattar, T., et al. 1993. FEBS Lett. 334: 161-164. PMID: 8224241
[4] Xu, X., et al. 1995. J. Biol. Chem. 270: 12398-12403. PMID: 7759480

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P310; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 13, 2020


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CATEGORIES

 APIs and Bioactives > Pyrimidine Synthesis Inhibitors


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