122852-69-1 Alosetron HCl AKSci J94459
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Alosetron HCl
, 95%
2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride

CAS Number:122852-69-1
MDL Number:MFCD03453647
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:285-291°C
Long-Term Storage:Store long-term at 2-8°C
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

Solubility:H2O: 5 mg/mL at warmed
Application(s):5-HT3 antagonist
Form:HCl salt


 Alosetron is a potent and selective 5-HT3 receptor antagonist. 5-HT3 receptors are nonselective cation channels that are extensively distributed on enteric neurons in the human gastrointestinal tract, as well as other peripheral and central locations. Activation of these channels and the resulting neuronal depolarization affect the regulation of visceral pain, colonic transit and gastrointestinal secretions, processes that relate to the pathophysiology of irritable bowel syndrome (IBS). 5-HT3 receptor antagonists such as alosetron inhibit activation of non-selective cation channels which results in the modulation of serotonin-sensitive GI motor and sensory processes.

[1]Andresen V, Hollerbach S: Reassessing the benefits and risks of alosetron: what is its place in the treatment of irritable bowel syndrome? Drug Saf. 2004;27(5):283-92.
[2] Camilleri M: Pharmacology and clinical experience with alosetron. Expert Opin Investig Drugs. 2000 Jan;9(1):147-59.
[3] Mayer EA, Bradesi S: Alosetron and irritable bowel syndrome. Expert Opin Pharmacother. 2003 Nov;4(11):2089-98.
[4] Rahimi R, Nikfar S, Abdollahi M: Efficacy and tolerability of alosetron for the treatment of irritable bowel syndrome in women and men: a meta-analysis of eight randomized, placebo-controlled, 12-week trials. Clin Ther. 2008 May;30(5):884-901.



Signal Word

Hazard Statements
H301; H319; H411

Precautionary Statements
P264; P270; P273; P280; P301+P310+P330; P305+P351+P338; P337+P313; P391; P405; P501

Current as of April 19, 2024

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 APIs and Bioactives > Serotonin Antagonists