136310-93-5 Tiotropium bromide AKSci J93545
 
 
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  J93545    
Tiotropium bromide, 95%
 
Spiriva
Tiova
IDENTITY
CAS Number:136310-93-5
MDL Number:MFCD00867027
MF:C19H22BrNO4S2
MW:472.42
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form:White to off-white to light yellow crystals or powder
Melting Point:217-230°C
Long-Term Storage:Store long-term at -20°C
HAZARDOUS MATERIALS INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 8mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):AChR; muscarinic receptor antagonist
Form:Bromide

REVIEW
 A muscarinic receptor antagonist, often referred to as an antimuscarinic or anticholinergic agent. Although it does not display selectivity for specific muscarinic receptors, on topical application it acts mainly on M3 muscarinic receptors located on smooth muscle cells and submucosal glands leading to a reduction in smooth muscle contraction and mucus secretion, thus producing a bronchodilatory effect.

REFERENCES
[1]Karner C, Chong J, Poole P (2012). Tiotropium versus placebo for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 7:CD009285. PMID 22786525.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 23, 2021


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CATEGORIES
 APIs and Bioactives > AChR Antagonists


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