Manual review is required before order is released.
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
REVIEW Danazol is a derivative of the synthetic steroid ethisterone, a modified progestogen, also known as 17-alpha-ethinyl testosterone. Danazol inhibits ovarian steroidogenesis resulting in decreased secretion of estradiol and may increase androgens. It is also used to treat fibrocystic breast disease (in patients unresponsive to simple measures) and for the prophylactic treatment of all types of hereditary angioedema in males and females. Danazol has antigonadotropic and anti-estrogenic activities. Danazol acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. In the treatment of endometriosis, as a consequence of suppression of ovarian function, danazol causes both normal and ectopic endometrial tissues to become inactive and atrophic. This leads to anovulation and associated amenorrhea.
Thomas GW, Rael LT, Bar-Or R, Mains CW, Slone DS, Boyd SR, Bar-Or D (2012). Biphasic effect of danazol on human vascular endothelial cell permeability and f-actin cytoskeleton dynamics. Biochem Biophys Res Commun. 421(4):707-12. PMID 22542943.
Uchiyama M, Jin X, Zhang Q, Hirai T, Bashuda H, Watanabe T, Amano A, Niimi M (2012). Danazol induces prolonged survival of fully allogeneic cardiac grafts and maintains the generation of regulatory CD4(+) cells in mice. Transpl Int. 25(3):357-65. PMID 22239184.
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.
WARNING: Attention California residents: This product can expose you to chemicals including Danazol, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.