122892-31-3 Itopride HCl AKSci J92152
 
 
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  J92152    AKSci Bulk Reagent
Itopride HCl, 95%
 
N-[[4-[2-(Dimethylamino)ethoxy]phenyl]methyl]-3,4-dimethoxy benzamidehydrochloride
N-[p-[2-(dimethylamino)ethoxy]benzyl]veratramide hydrochloride
Itax
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IDENTITY
CAS Number:122892-31-3
MDL Number:MFCD00881710
MF:C20H27ClN2O4
MW:394.89
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:190-197°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:H2O: 48mg/mL
Application(s):Dopamine D2 receptor Inhibitor; Acetylcholinesterase Inhibitor
Form:HCl salt

REVIEW
 Itopride is indicated for the treatment of functional dyspepsia and other gastrointestinal conditions. Itopride increases acetylcholine concentrations by inhibiting dopamine D2 receptors and acetylcholinesterase. Higher acetylcholine increases GI peristalsis, increases the lower esophageal sphincter pressure, stimulates gastric motility, accelerates gastric emptying, and improves gastro-duodenal coordination.

REFERENCES
[1]Iwanaga Y, Suzuki N, Kato K, Kimura T, Morikawa K, Kato H, Ito Y, Gomi Y (1993). Stimulatory effects of HSR-803 on ileal motor activity. Jpn J Pharmacol. 62(4):395-401. PMID 8230867.
[2] Takahara E, Fukuoka H, Takagi T, Nagata O, Kato H (1992). Simultaneous determination of a new gastrointestinal prokinetic agent (HSR-803) and its metabolites in human serum and urine by high-performance liquid chromatography using automated column-switching. J Chromatogr. 576(1):174-8. PMID 1500454.
[3] Iwanaga Y, Miyashita N, Morikawa K, Mizumoto A, Kondo Y, Itoh Z (1990). A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Gastroenterology. 99(2):401-8. PMID 2365190.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H410

Precautionary Statements
P264; P270; P273; P301+P312; P330; P391; P501

Current as of January 13, 2025


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