56-17-7 Cystamine dihydrochloride AKSci J90948
 
 
Loading Please Wait...
  J90948    AKSci Bulk Reagent
Cystamine dihydrochloride
, 95%, for synthesis
 
Bis(2-aminoethyl) disulfide dihydrochloride
2,2''-Dithiobis(ethylamine) dihydrochloride
2,2''-Diaminodiethyl disulfide dihydrochloride
more..




IDENTITY
CAS Number:56-17-7
MDL Number:MFCD00012905
MF:C4H12N2S2.2HCl
MW:225.20
EINECS:200-260-7
BRN:3616850
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%, for synthesis
Physical Form (at 20°C):Solid
Melting Point:214-222°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Transglutaminase
Form:2HCl salt

REVIEW

 Cystamine dihydrochloride is transglutaminase inhibitor which is being investigated as a treatment as a neuroprotective agent for neurodegenerative diseases, e g., Huntingdon's diseases. Cystamine dihydrochloride is also a radiation-protective agent that interferes with sulfhydryl enzymes. It may also protect against carbon tetrachloride liver damage. The compound is also being investigated as an anti-HIV agent.

REFERENCES
[1]C Gibrat, F Cicchetti, Potential of cystamine and cysteamine in the treatment of neurodegenerative diseases. Prog Neuropsychopharmacol Biol Psychiatry. 2011;35(2):380-9.
[2] A Dedeoglu, JK Kubilus, TM Jeitner, SA Matson, M Bogdanov, NW Kowall, WR Matson, AJ Cooper, RR Ratan,MF Beal, SM Hersch, RJ Ferrante. Therapeutic effects of cystamine in a murine model of Huntington''s disease. J Neurosci. 2002 Oct 15;22(20):8942-50.
[3] M Borrell-Pagès, JM Canals, FP Cordelières, JA Parker, JR Pineda, G Grange, EA Bryson, M Guillermier, E Hirsch, P Hantraye, ME Cheetham, C Néri, J Alberch, E Brouillet, F Saudou, S, Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase. J Clin Invest. 2006 May;116(5):1410-24.
[4] JI Toohey: Sulfur metabolism in AIDS: cystamine as an anti-HIV agent.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of March 3, 2024


Download SDS Request COA

⚠️
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives >


PubChem
  @PubMed